My Breast is the true story of Joyce Wadler (Meredith Baxter, Family Ties), a plucky, high-profile magazine writer who discovers a lump in her breast. When the lump is diagnosed as malignant, she must make the difficult decision of choosing between two surgeries: a lumpectomy or a mastectomy. Joyce's friends rally to her side, but her selfish boyfriend, Nick (Jamey Sheridan, Law & Order: Criminal Intent), can't bring himself to acknowledge her condition.
After undergoing a lumpectomy, Joyce receives wonderful news - the cancer hasn't spread. However, her celebration with Nick is short-lived and the two soon part. When Nick returns to rekindle their romance, Joyce decides it's time to take stock of her relationships and shed her old baggage once and for all.