At the start of the new college semester, Eloi and Alexandre encounter Andre, the most brilliant student in the lecture hall. Fascinated by his ease and charisma, they quickly fall under his spell. Andre then offers them his friendship in exchange for complete loyalty to him. Lost in admiration, Eloi and Alexandre devotedly submit to this rigorous discipline - up until the day that Andre abandons them. Eloi and Alexandre now have no other choice than to stand on their own. Poison Friends was the opening film and Grand Prize Winner in the International Critics' Week at Cannes 2006.