During a 2005 high school class trip to Aruba, a carefree night out with friends turns tragic when teenager Natalee Holloway fails to show up for her return flight home to Alabama. When Natalee disappears without a trace, her celebratory island vacation becomes a harrowing nightmare for her family. And with no clue as to her whereabouts, her mother, Beth Twitty (Tracy Pollan), is launched into a frustrating search that spans more than four years. Along with her husband George (Grant Show) and her best friend Carol (Catherine Dent), Beth struggles to uncover the truth. As a trio of suspects are arrested and then released because of a lack of evidence, Beth's quest for justice provides the backdrop for a cautionary tale about the dangers of international travel. Based on the book by Beth Holloway-Twitty.